Abstract: OBJECTIVES: To assess combat and combat-related posttraumatic stress disorder (PTSD) as risk factors for heart disease and noncardiac chronic disease comorbidity in deployed Vietnam veterans 50 years post-War. METHODS: A random sample of 12,400 veterans was surveyed in 1984 & 1998, and a deployed subset (n=729) in 2000. Outcomes included probable PTSD and history of diagnosed chronic illnesses. RESULTS: Twenty-eight percent reported a diagnosed heart condition; combat exposure in Vietnam was a significant predictor (odds ratio = 1.92, 95% confidence interval = 1.13-3.31). Veterans with heart disease reported significantly more comorbid chronic illnesses, including arthritis and respiratory conditions: sleep apnea, emphysema, and asthma. Chronic illnesses were reported more often by men with PTSD. CONCLUSIONS: Emerging evidence suggests that 50 years after Vietnam combat and associated PTSD may contribute to heart disease and comorbid conditions.